Asymmetric Synthesis of 2-Alkyl(Aryl)-2,3-dihydro-4-pyridones by Addition of Grignard Reagents to Chiral 1-Acyl-4-methoxypyridinium Salts

DOI: 10.1021/jo00296a006

Source and publish data:

Journal of Organic Chemistry p. 2574 - 2576 (1990)

Update date:2022-09-26

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Authors:

Comins, Daniel L.

Goehring, R. Richard

Joseph, Sajan P.

O'Connor, Sean

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Article abstract of DOI:10.1021/jo00296a006

Grignard addition to a chiral 1-acyl-4-methoxypyridinium salt provides synthetically useful 2-alkyl(aryl)-2,3-dihydro-4-pyridones in high diastereomeric excess.

Full text of DOI:10.1021/jo00296a006

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