Controlled endocyclic and exocyclic-γ-metalations of β-substituted cyclohexenyl sulfones. Regiospecific syntehses of γ-oxygenated cyclohexenyl sulfones.

Article abstract of DOI:10.1016/0040-4039(91)80632-G

β-Substituted cyclohexenyl sulfones may be regiospecifically isomerized to either endocyclic or exocyclic allyl sulfones. Epoxidation of these materials followed by a second metalation yields γ-hydroxy cyclohexenyl sulfones 6 and 7. Subjection of either o