Synthesis and Antifolate Evaluation of the 10-Propargyl Derivatives of 5-Deazafolic Acid, 5-Deazaaminopterin, and 5-Methyl-5-deazaaminopterin

DOI: 10.1021/jm00080a019

Source and publish data:

Journal of Medicinal Chemistry p. 332 - 337 (1992)

Update date:2022-07-30

Topics:

Authors:

Piper, J. R.

Malik, N. D.

Rhee, M. S.

Galivan, J.

Sirotnak, F. M.

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Article abstract of DOI:10.1021/jm00080a019

5-Deaza-10-propargylfolic acid (4), an analogue of the thymidylate synthase (TS) inhibitor 10-propargyl-5,8-dideazafolic acid (PDDF, 1), was prepared via alkylation of diethyl N-<4-(propargylamino)benzoyl>-L-glutamate (7) by 2-amino-6-(bromomethyl)-4(3H)-

Full text of DOI:10.1021/jm00080a019

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