Synthesis and Antifolate Evaluation of the 10-Propargyl Derivatives of 5-Deazafolic Acid, 5-Deazaaminopterin, and 5-Methyl-5-deazaaminopterin

DOI: 10.1021/jm00080a019

Source and publish data:

Journal of Medicinal Chemistry p. 332 - 337 (1992)

Update date:2022-07-30

Topics:

Authors:

Piper, J. R.

Malik, N. D.

Rhee, M. S.

Galivan, J.

Sirotnak, F. M.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00080a019

5-Deaza-10-propargylfolic acid (4), an analogue of the thymidylate synthase (TS) inhibitor 10-propargyl-5,8-dideazafolic acid (PDDF, 1), was prepared via alkylation of diethyl N-<4-(propargylamino)benzoyl>-L-glutamate (7) by 2-amino-6-(bromomethyl)-4(3H)-

Full text of DOI:10.1021/jm00080a019

Products guided by the article

Product name:L-Glutamic acid, N-[4-[[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methyl]-2-propynylamino] benzoyl]-, diethyl ester

Cas No:135423-82-4

R&D Labs maybe for 135423-82-4

Taizhou Elitechemie MediPharma Technology Co.,Ltd.

Contact:+86-523-86810021

Address:Building G14,NO.1 Avenue,China Medical City, Taizhou, Jiangsu,China
Wuhan Jadechem International Trade Co.,Ltd.

website:http://www.jadechem-intl.com

Contact:+86-27-83527060

Address:Room 502,Building C11,Software new city No.8,Huacheng Avenue,East Lake High-tech development zone,Wuhan,Hubei,China
Santow Laboratory Limited

Contact:+86-371-55981030

Address:Room 1571, Macalline Soho, No.1, Shangdu Road, Zhengzhou, Henan
Nanjing Chemical Material Corp.(NCMC)

website:http://www.njchemm.com

Contact:0086-25-83172879

Address:B12 Technology and Innovation Building, Nanjing Tech University, No.5 New Model Road
Shenyang Xingzhenghe Chemical Co., Ltd.

Contact:024-23509232

Address:No. 33, Naner Road, Heping Dist.

Relevant to this article

Die Carbonylchrom-, Carbonylmolybdaen- und Carbonylwolfram-Komplexe der Unsymmetrisch Substituierten Phosphinoschwefeldiimide ^tBu2P(NSN)PPh2 und ^tBu2P(NSN)P(^tBu)Ph. 1H, 13C und 31P NMR-Spektroskopische Charakterisierung

Doi:10.1016/0022-328X(91)80005-5
(1991)
Oxime Esters as Novel Irreversible Acyl Transfer Agents for Lipase Catalysis in Organic Media

Doi:10.1039/c39890001533
(1989)
Synthesis and in vitro evaluation of 2-[¹¹C]methoxyestradiol-3, 17β-O,O-bissulfamate for in vivo studies of angiogenesis

Doi:10.1002/jlcr.1930
(2011)
Synthesis of hydroxyl-containing oxindoles and 3,4-dihydroquinolin-2-ones through oxone-mediated cascade arylhydroxylation of activated alkenes

Doi:10.1039/d0gc02205e
(2020)
Synthesis, crystal structure and ab initio studies of 5-Phenylamino-3- phenylimino-3H[1, 2]dithiole-4-carboxylic acid ethyl ester

Doi:10.1007/s10870-011-0196-2
(2011)
Pyrrole alkanoic acid derivatives as nuisance inhibitors of microsomal prostaglandin E₂ synthase-1

Doi:10.1016/j.ejmech.2011.12.009
(2012)

Article Doi