Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: New reductive alkylating DNA cleaving agents

DOI: 10.1021/jm00114a003

Source and publish data:

Journal of Medicinal Chemistry p. 2954 - 2961 (1991)

Update date:2022-07-30

Topics:

Authors:

Islam Islam

Skibo Skibo

Dorr Dorr

Alberts Alberts

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Article abstract of DOI:10.1021/jm00114a003

Described herein are structure-activity studies of new antitumor agents based on the pyrrolo[1,2-a]benzimidazole (PBI) ring system. These compounds were designed as new DNA cross-linkers mimicking the mitomycin antitumor agents. Actually, the PBI derivati

Full text of DOI:10.1021/jm00114a003

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