Cyclopentylamine substituted triazolo[4,5-D]pyrimidine: Implications for binding to the adenosine receptor

Article abstract of DOI:10.1016/0040-4039(91)80840-3

3-(3-chlorophenyl)-7-(N-cyclopentylamino)-5-methylthio-1,2,3-triazolo[ 4,5-d]pyrimidine was found to have restricted rotation around the exocyclic C-N bond. This has implications for the orientation of hydrophobic substituents relative to the plane of the