Journal of Organic Chemistry p. 5610 - 5614 (1991)
Update date:2022-07-30
Topics:
Strekowski, Lucjan
Wydra, Roman L.
Janda, Lubomir
Harden, Donald B.
4,5-Dimethyl- and 4,5,6-trimethyl-substituted pyrimidines are brominated at C5-Me with NBS in CCl4 and at C4(6)-Me with bromine in acetic acid to give the corresponding bromomethyl derivatives in a high yield.The remaining methyl group(s) can also be brominated with high regioselectivity.The 2-methylthio substituent is not oxidized under these conditions.
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