Journal of Organic Chemistry p. 4925 - 4929 (1991)
Update date:2022-07-29
Topics:
Resnati, Giuseppe
DesMarteau, Darryl D.
The N-fluorobis<(trifluoromethyl)sulfonyl>imide (1) has been used in the electrophilic fluorination of the lithium enolate of esters, amides, and ketones.The corresponding α-fluorocarbonyl compounds have been obtained in good yields.The α-fluorination of β-diesters, β-diamides, β-keto esters, and β-diketones has been performed either on the neutral compounds or on the metal enolates.In this way some geminal azafluoro, chlorofluoro, fluorooxy compounds have been prepared in nearly quantitative yields.Also some α-keto esters and acids have been selectively monofluorinated in the β-position by simple treatment of the neutral compound with 1.
View MoreRefine Chemicals Science & Technology Technology Developing Co., Ltd.
Contact:+86-22-87899130
Address:No.12,west keyan road,Tianjin City
JiYi Chemical (Beijing) Co., Ltd.
Contact:+86-10-89385733
Address:Shilou Town of Fangshan District, Beijing
Contact:+86-25-85281586
Address:13F,Bld2#,South of Longpan Road
Shandong Wanda Organosilicon New Material Co., Ltd
Contact:+86-21-54177116;54302881
Address:R1318 Greenland No. 3 Lane 58 Xinjian East Rd., Minhang
Anhui Redstar Pharmaceutical Corp., Ltd
Contact:+86-563-5120837
Address:Jingxian Industrial Development Zone, Anhui , China
Doi:10.1021/acs.joc.5b00769
(2015)Doi:10.3184/174751911X13179842027190
(2011)Doi:10.1002/jhet.681
(2012)Doi:10.1246/bcsj.64.2128
(1991)Doi:10.1016/0040-4039(91)80677-X
(1991)Doi:10.1021/ja00020a049
(1991)