Nucleotides. Part XXXV. Synthesis of 3'-deoxyadenylyl-(2'-5')-3'-deoxyadenylyl-(2'-ω)-9-(ω-hydroxyalkyl)adenines

DOI: 10.1002/hlca.19910740419

Source and publish data:

Helvetica Chimica Acta p. 887 - 891 (1991)

Update date:2022-07-29

Topics:

Authors:

Mikhailov, Sergey N.

Charubala, Ramamurthy

Pfleiderer, Wolfgang

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1002/hlca.19910740419

Via the phosphotriester approach, new structural analogs of (2'-5')oligoadenylates, namely 3'-deoxyadenylyl-(2'-5')-3'-deoxyadenylyl-(2'-ω)-9-(ω-hydroxyalkyl)adenines 18-21, have been synthesized (see Scheme) which should preserve biological activity and show higher stability towards phosphodiesterases.The newly synthesized oligonucleotides 18-21 have been characterized by 1H-NMR spectra, TLC, and HPLC analysis.

Full text of DOI:10.1002/hlca.19910740419

Products guided by the article

Product name:3'-Deoxy-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-(2'-(O^P-<2-(4-nitrophenyl)ethyl>)->5')-3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-(2'-(O^P-<2-(4-nitrophenyl)ethyl>)->3')-N⁶-benzoyl-9-(3'-hydroxypropy...

Cas No:135711-66-9

R&D Labs maybe for 135711-66-9

Wuhan Shengmao Corp

website:http://www.shengmaochem.com

Contact:86-27-82853423, 82819281

Address:Rm 202, A Unit Huaqiao Building No. 2, Lihuangpi Road, Wuhan, China
Chengdu King-tiger Pharm-chem. Tech. Co., Ltd

Contact:028-85317716

Address:Tianfu Life Science Park, No. 88 South Keyuan Road, Gaoxin District, Chengdu City, Sichuan Province, PRC.
SHIFANG SUHONG CHEMICAL CO.,LTD

Contact:+86-838-2224563

Address:Room 1207 Zongchen Sunshine No.128 Taishan South Road,Deyang City,Sichuan China
Chengdu Gelipu Biotechnology Co., Ltd.

website:http://www.glp-china.com

Contact:86-28-82610909

Address:chegndu
Jiangsu Dacheng Pharmaceutical and Chemical Co.,Ltd

Contact:+86-0517-87036900

Address:Chuzhou Chemical park, Huai'an, Jiangsu Province

Relevant to this article

Synthesis of functionalized benzoboroxoles for the construction of boronolectins

Doi:10.1055/s-0031-1289577
(2011)
Doi:10.1021/jo50014a013
(1953)
Synthesis and bio-evaluation of indole-chalcone based benzopyrans as promising antiligase and antiproliferative agents

Doi:10.1016/j.ejmech.2017.11.015
(2018)
Multi-component reaction-functionalized chitosan complexed with copper nanoparticles: An efficient catalyst toward A³ coupling and click reactions in water

Doi:10.1002/aoc.5074
(2019)
Pyrrolidine-thioxotetrahydropyrimidinone as an efficient organocatalyst for the enantioselective Michael addition of cyclic ketones to nitrodienes

Doi:10.1016/j.tet.2012.07.078
(2012)
An efficient and convenient synthesis of acyl coa: Monoacylglycerol acyltransferase 2 inhibitor, 2-[2-(4-tert-butylphenyl)ethyl]-N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide

Doi:10.3987/COM-15-13387
(2016)

Article Doi