Nucleotides. Part XXXV. Synthesis of 3'-deoxyadenylyl-(2'-5')-3'-deoxyadenylyl-(2'-ω)-9-(ω-hydroxyalkyl)adenines

DOI: 10.1002/hlca.19910740419

Source and publish data:

Helvetica Chimica Acta p. 887 - 891 (1991)

Update date:2022-07-29

Topics:

Authors:

Mikhailov, Sergey N.

Charubala, Ramamurthy

Pfleiderer, Wolfgang

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Article abstract of DOI:10.1002/hlca.19910740419

Via the phosphotriester approach, new structural analogs of (2'-5')oligoadenylates, namely 3'-deoxyadenylyl-(2'-5')-3'-deoxyadenylyl-(2'-ω)-9-(ω-hydroxyalkyl)adenines 18-21, have been synthesized (see Scheme) which should preserve biological activity and show higher stability towards phosphodiesterases.The newly synthesized oligonucleotides 18-21 have been characterized by 1H-NMR spectra, TLC, and HPLC analysis.

Full text of DOI:10.1002/hlca.19910740419

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