Synthesis and QSAR study of novel cytotoxic spiro[3H-indole-3, 2′(1′H)-pyrrolo[3,4-c]pyrrole]-2,3′,5′(1H,2′aH, 4′H)-triones

DOI: 10.1016/j.ejmech.2011.10.058

Source and publish data:

European Journal of Medicinal Chemistry p. 312 - 322 (2012)

Update date:2022-08-04

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Authors:

Girgis, Adel S.

Stawinski, Jacek

Ismail, Nasser S.M.

Farag, Hanaa

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Article abstract of DOI:10.1016/j.ejmech.2011.10.058

1,3-Dipolar cycloaddition reaction of 1-aryl-1H-pyrrole-2,5-diones 1a-e with non-stabilized azomethine ylides, generated in situ via decarboxylative condensation of isatins 2a-c and sarcosine (3) in refluxing ethanol, afforded 4′-aryl-5′a,6′-dihydro-1′-me

Full text of DOI:10.1016/j.ejmech.2011.10.058

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