Stereoselective Total Synthesis of Polyether Ionophore Antibiotics, Isolasalocid A and Lasalocid A. Part 1. Stereocontrolled Construction of the C Rings (C18-C24) by Acid-Catalyzed Cyclization of p-Methoxyphenylallyl Alcohols

DOI: 10.1016/S0040-4020(01)87184-2

Source and publish data:

Tetrahedron p. 5979 - 5996 (1993)

Update date:2022-08-04

Topics:

Authors:

Horita, Kiyoshi

Noda, Ichio

Tanaka, Kazuhiro

Miura, Tamaki

Oikawa, Yuji

Yonemitsu, Osamu

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Article abstract of DOI:10.1016/S0040-4020(01)87184-2

The C18-C24 subunits (11, 12) of isolasalocid A (9) and lasalocid A (10) were synthesized stereoselectively via construction of the tetrahydrofuran and tetrahydropyran rings by acid-catalyzed cyclization of the corresponding p-methoxyphenylallyl alcohols (18, 25). Key words: polyether antibiotic; total synthesis; stereoselective synthesis; tetrahydrofuran; tetrahydropyran; acid-catalyzed cyclization.

Full text of DOI:10.1016/S0040-4020(01)87184-2

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