The Preparation and Reaction of Fluorinated Phenyl Mono- or Bis- Cadmium and Copper Reagents

Article abstract of DOI:10.1016/S0022-1139(00)80141-4

Tetrafluorodibromobenzenes react readily with acid-washed cadmium in DMF at temperatures ranging from 25 deg C to 60 deg C to give bromotetrafluorophenylcadmium reagents in excellent yields.Treatment of the mono- cadmium reagent solution with excess cadmium at 100 deg C affords the tetrafluorophenylbiscadmium reagents.The mono- and bis- copper reagents are obtained via metathesis of the corresponding cadmium reagents with cuprous bromide at room temperature.Allylation and acylation of the biscopper reagents give the corresponding allylated and acylated tetrafluoro-benzenes, respectively.