Isopenicillin N Synthase: A New Mode of Reactivity

DOI: 10.1039/c39910000736

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 736 - 738 (1991)

Update date:2022-09-26

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Authors:

Baldwin, Jack E.

Lynch, Gregory P.

Schofield, Christopher J.

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Article abstract of DOI:10.1039/c39910000736

Incubation of δ-(L-α-aminoadipoyl)-L-(3,3-difluorohomocysteinyl)-D-valine with isopenicillin N synthase gave a thiocarboxylic acid, consistent with the formation of a monocyclic lactam intermediate.

Full text of DOI:10.1039/c39910000736

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