Design, synthesis and structure-activity relationship of novel Relacin analogs as inhibitors of Rel proteins

Article abstract of DOI:10.1016/j.ejmech.2013.10.036

Rel proteins in bacteria synthesize the signal molecules (p)ppGpp that trigger the Stringent Response, responsible for bacterial survival. Inhibiting the activity of such enzymes prevents the Stringent Response, resulting in the inactivation of long-term