An expedient large-scale preparation of a dibenz[b,e]oxepinone derivative

Article abstract of DOI:10.1080/00397919808005948

A convenient, large-scale synthesis of a dibenz[b,e]oxepinone derivative is described. The dibenz[-b,e]oxepinone ring system is constructed using an iron chloride catalyzed intramolecular Friedel-Crafts cyclization of an appropriate phenoxymethylbenzoic acid chloride in toluene, reagents and conditions that are economically and environmentally compatible with large- scale preparation.

Full text of DOI:10.1080/00397919808005948

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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An Expedient Large-
Scale Preparation of a
Dibenz[b,e]oxepinone
Derivative
Thomas B.K. Lee a , Andrew J. Tebben a , Franz J.
Weiberth a & George S.K. Wong a
a Chemical Development Hoechst Marion Roussel,
Inc. , Bridgewater, NJ, 08807 - 0800
Published online: 02 Sep 2006.
To cite this article: Thomas B.K. Lee , Andrew J. Tebben , Franz J. Weiberth
& George S.K. Wong (1998) An Expedient Large-Scale Preparation of a
Dibenz[b,e]oxepinone Derivative, Synthetic Communications: An International
Journal for Rapid Communication of Synthetic Organic Chemistry, 28:4, 747-751, DOI:
10.1080/00397919808005948
To link to this article: http://dx.doi.org/10.1080/00397919808005948
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