A Synthesis of C1-C22 Fragment of the Immunosuppressant FK 506. Stereoselective Construction of (E)-Trisubstituted Double Bond (C19-C20) via Ester-enolate Claisen Rearrangement

DOI: 10.1016/0040-4039(91)80646-N

Source and publish data:

Tetrahedron Letters p. 2909 - 2912 (1991)

Update date:2022-07-29

Topics:

Authors:

Morimoto, Yoshiki

Mikami, Atsushi

Kuwabe, Shin-itsu

Shirahama, Haruhisa

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Article abstract of DOI:10.1016/0040-4039(91)80646-N

An ene-ester 5 prepared from L-malic acid was subjected to the ester-enolate Claisen rearrangement under Ireland's condition to give stereoselectively C16-C22 fragment 11 containing (E)-trisubstituted double bond which was further advanced to C1-C22 fragm

Full text of DOI:10.1016/0040-4039(91)80646-N

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