Expedient enantiospecific synthesis of RP 73613: A new selective non-peptide NK1 antagonist

Article abstract of DOI:10.1016/0040-4039(96)01760-1

The synthesis of RP 73613 was achieved in 13 steps with an overall yield of 12%. The strategy was based on a [3 + 2] azomethine ylid dipolar cycloaddition to generate the bicyclic framework and the asymmetric was introduced by resolution.