Versatile Stereoselective Synthesis of Completely Protected Trifunctional α-Methylated α-Amino Acids Starting from Alanine

Article abstract of DOI:10.1002/hlca.19910740414

A new route to completely protected α-methylated α-amino acids starting from alanine is described (see Scheme).These derivatives, which are obtained via base-catalyzed opening of the oxazolidinones (2S,4R)- and (2R,4S)-2, can be directly employed in pepti