Improved synthesis of L-homoserine derivatives from L-aspartic acid

Article abstract of DOI:10.1055/s-1991-26507

N-Alkoxycarbonyl-L-homoserine lactones (α-alkoxycarbonyl-amino-γ-butyrolactones) were prepared by selective esterification of L-aspartatic acid followed by N-protection, precipitation of the dicyclohexylammonium salts, chemoselective reduction with lithium borohydride, and cyclization to the corresponding γ-lactones during isolation.