Axially chiral N-heterocyclic carbene gold(I) complex catalyzed asymmetric Friedel-Crafts/cyclization reaction of nitrogen-tethered 1,6-enynes with indole derivatives

DOI: 10.1016/j.tetasy.2011.12.004

Source and publish data:

Tetrahedron Asymmetry p. 2029 - 2038 (2011)

Update date:2022-08-04

Topics:

Authors:

Yang, Jinming

Zhang, Rui

Wang, Wenfeng

Zhang, Zhen

Shi, Min

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Article abstract of DOI:10.1016/j.tetasy.2011.12.004

A class of axially chiral NHC-Au(I) complexes has been applied to the asymmetric Friedel-Crafts/cyclization reaction of 1,6-enynes 14 with indole derivatives 15, affording the corresponding Friedel-Crafts and intramolecular cyclization products 16 in good yields with moderate ee values under mild conditions.

Full text of DOI:10.1016/j.tetasy.2011.12.004

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Product name:1-methyl-3-((4-methylene-1-tosylpyrrolidin-3-yl)(phenyl)methyl)-1H-indole

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