Total syntheses of (-)-hanishin, (-)-longmide B, and (-)-longmide B methyl ester via a novel preparation of N-substituted pyrrole-2-carboxylates

Article abstract of DOI:10.1021/ol203433c

A novel preparation of N-substituted pyrrole-2-carboxylates has been developed based upon 1,3-dipolar cycloaddition and a conventional hydrogenolysis. By using this method as the key step, total syntheses of natural alkaloids (-)-hanishin, (-)-longmide B,