One-pot synthesis of 2H-pyrano[2,3-d]pyrimidine derivatives

Article abstract of DOI:10.1007/s00706-011-0602-7

The reaction between dialkyl acetylenedicarboxylate and a 1,1-diactivated alkene in the presence of Ph₃P leads to 2H-pyrano[2,3-d]pyrimidine derivatives and highly substituted dialkyl (2E)-2-[(1,3-dimethyl-2,4,6- trioxotetrahydropyrimidin-5(2H)-ylidene)arylmethyl]-2-butenedioate in fair to good yields at room temperature and under neutral conditions.