Preparation of chiral key intermediates of morpholine based neurokinin receptor antagonists by asymmetric allylic alkylation

DOI: 10.1016/j.tet.2013.05.097

Source and publish data:

Tetrahedron p. 6424 - 6430 (2013)

Update date:2022-07-30

Topics:

Authors:

Keldenich, Jér?me

Denicourt-Nowicki, Audrey

Michon, Christophe

Agbossou-Niedercorn, Francine

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Article abstract of DOI:10.1016/j.tet.2013.05.097

Abstract The preparation of optically active morpholine-2-aryl-2-allyl derivative from morpholine-2-aryl-3-ones is reported. The optically active tetrasubstituted stereocenter is introduced during a palladium promoted asymmetric allylic alkylation. The re

Full text of DOI:10.1016/j.tet.2013.05.097

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