Tetrahedron Letters p. 3663 - 3666 (1991)
Update date:2022-08-03
Topics:
Shih
Holmes
Mrozik
Fisher
The Wittig condensation of (2R,3R,4E)-2,6-dimethyl-3-trimethylsilyloxy-4- heptenyltriphenylphosphorylidene with aldehyde 1 produced the desired cis olefin 11 in 45% yield. Treatment of this intermediate with pyridinium tosylate in methanol effected spiroketalization and desilylation with hydrogen fluoride-pyridine in THF afforded the avermectin-nemadectin hybrid 2.
View MoreAnhui Biochem United Pharmaceutical Co., Ltd.
Contact:0086 551 5167062 / 5228268
Address:No. 30 Hongfeng Road, Hi-Tech Development Zone, Hefei (230088), China
Beijing Cooperate Pharmaceutical Co.,Ltd
website:http://www.cooperate-pharm.com/
Contact:86-01060279497
Address:No.507,Building 4,Tianhua Street, Biomedicine industrial Base
Shanghai better-in Medical Technology Co.,LTD.
Contact:+86-21-38921049
Address:Lane 720 zhangjianggaoke cailun road, Pudong, Shanghai, room 513
Wuhan Konberd Biotech Co., Ltd.
Contact:+86-27-87205925
Address:NO.666, Gaoxin Road, Eastlake High-tech zone
Shanghai shibo Chemical Co., Ltd
Contact:+86-021-60753516
Address:688 Qiushi Road, Jinshan High-tech Park, Shanghai, China,201512
Doi:10.1016/j.ejmech.2012.01.040
(2012)Doi:10.1016/j.tetlet.2012.10.087
(2012)Doi:10.1021/jm201713h
(2012)Doi:10.1021/jm201717y
(2012)Doi:10.1016/0022-328X(91)83052-6
(1991)Doi:10.1007/s00726-010-0665-5
(2011)
