Synthesis of γ-Lactones by the Intramolecular Radical Cyclization of 2-Bromo-3,3-bis(methylthio)propionates. A Useful Ketene Radical Synthon

DOI: 10.1246/cl.1991.1457

Source and publish data:

Chemistry Letters p. 1457 - 1460 (1991)

Update date:2022-08-04

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Authors:

Iwasa, Seiji

Yamamoto, Makoto

Furusawa, Atsuko

Kohmoto, Shigeo

Yamada, Kazutoshi

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Article abstract of DOI:10.1246/cl.1991.1457

The first example of intramolecular radical cyclization of ketene radical synthon is presented.Intramolecular radical cylization of 2-bromo-ketene-S,S-acetals proceeded highly regioselectively to give the corresponding 5-exo-trig cyclized γ-lactones.

Full text of DOI:10.1246/cl.1991.1457

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Product name:2(3H)-Furanone, 3-[bis(methylthio)methylene]dihydro-4-(phenylmethyl)-

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