Organic Letters
Letter
Functional Molecular Design & Synthesis (No. 130028832).
We also thank Dr. Zhong-Yan Cao for helpful discussions.
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p-toluenesulfonyl radical at the same time. Finally, interaction
of FCu(II)CNLn A with p-toluenesulfonyl radical gave rise to
TsF as well as regenerated the active Cu(I)CNLn.
In summary, we report an unprecedented Cu-catalyzed
intermolecular alkyl Csp3−H cyanation of N-fluorotosylamide
derivatives for the first time, enabling the preparation of
versatile nitrile compounds under mild reaction condition. The
reaction overrides the common preference for intramolecular
̈
amination within the classic Hofmann−Loffler−Freytag
manifold and can be used for the late-stage functionalization
of natural product derivatives. Application of the current
strategy to asymmetric version is underway in our laboratory.
ASSOCIATED CONTENT
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Accession Codes
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tallographic data for this paper. These data can be obtained
Cambridge Crystallographic Data Centre, 12 Union Road,
Cambridge CB2 1EZ, UK; fax: +44 1223 336033.
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AUTHOR INFORMATION
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Corresponding Author
ORCID
Mun
C. Q.; Fernandez, P.; Martínez, C.; Mun
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Notes
The authors declare no competing financial interest.
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ACKNOWLEDGMENTS
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This project was supported by the National Natural Science
Foundation of China (21801250), the Fundamental Research
Funds for the Central Universities (18CX02141A), and the
open project of Jilin Province Key Laboratory of Organic
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Org. Lett. XXXX, XXX, XXX−XXX