Enantioselective Synthesis of a 9,10-seco-Taxane Derivative via Electrophilic Epoxy-allylsilane Ring Closure

DOI: 10.1039/c39930001823

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1823 - 1825 (1993)

Update date:2022-08-03

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Authors:

Pettersson, Lars

Frejd, Torbjoern

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Article abstract of DOI:10.1039/c39930001823

seco-Taxane 8, a potential starting material for further development into highly substituted taxanes, is synthesized by BF3*OEt2 treatment of epoxy-allylsilane 7, in its turn synthesized by joining an A-ring derivative 2 with a C-ring precursor chain 3.

Full text of DOI:10.1039/c39930001823

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