Chemical and Pharmaceutical Bulletin p. 1760 - 1772 (1991)
Update date:2022-08-05
Topics:
Sato
Dan
Onuma
Tanaka
Aoki
Koga
A series of substituted 7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acids and 7,8-dihydrofuro[2,3-g]benzoxazole-7-carboxylic acids were synthesized and evaluated for uricosuric and diuretic activities in rats. Many of the benzisoxazole derivatives showed uricosuric and only weak diuretic activities, whereas the benzoxazoles exhibited potent diuretic activities with little affecting urate excretion. Among these compounds, 5-chloro-7,8-dihydro-3-phenylfuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid (AA-193) was found to be a potent uricosuric agent without diuretic activity and was selected for further development.
View Morewebsite:http://www.oceanchem-group.com
Contact:86-536-8596048
Address:9th floor,Building B future Plaza, No.88.Fenghuang Street,Weifang,Shandong,China
Guangxi Shanyun Biochemical Science and Technology Co., Ltd
Contact:+86-0772--6828887
Address:#2 Industrial Park of Luzhai County, Liuzhou, Guangxi, China
Shanghai Send Pharmaceutical Technology Co., Ltd.
website:http://www.shsendpharma.com
Contact:021-58088081, +8613585868794
Address::Room A601, Building 1,NO. 800 Qingdai Road Pudong District Shanghai,China
Guilin Zhenda Bio-Tech Co., Ltd.
Contact:86-773-3568977
Address:-Yangtang shangshui industry park, Lingui county,
Weifang Jahwa Chemical Co.,Ltd
Contact:0086-536-8897731,8897730
Address:No.5166 East Dongfeng Street,Weifang,Shandong,China
Doi:10.1016/j.ejmech.2010.01.040
(2010)Doi:10.1021/jo00023a010
(1991)Doi:10.1248/cpb.39.1866
(1991)Doi:10.1016/S0040-4020(01)85058-4
(1994)Doi:10.1246/bcsj.64.2588
(1991)Doi:10.1021/j100180a035
(1992)
