Chemical and Pharmaceutical Bulletin p. 1760 - 1772 (1991)
Update date:2022-08-05
Topics:
Sato
Dan
Onuma
Tanaka
Aoki
Koga
A series of substituted 7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acids and 7,8-dihydrofuro[2,3-g]benzoxazole-7-carboxylic acids were synthesized and evaluated for uricosuric and diuretic activities in rats. Many of the benzisoxazole derivatives showed uricosuric and only weak diuretic activities, whereas the benzoxazoles exhibited potent diuretic activities with little affecting urate excretion. Among these compounds, 5-chloro-7,8-dihydro-3-phenylfuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acid (AA-193) was found to be a potent uricosuric agent without diuretic activity and was selected for further development.
View Morewebsite:http://www.acrospharmatech.com
Contact:+1-3234804688
Address:Flat/RM 1502,Easey Commercial building 253-261 Hennessy Road,Wanchai，HongKong
Zipont chem(wuhan）Tech co.，Ltd
Contact:+86-27-87587198
Address:wuhan
Changzhou Sunlight Pharmaceutical Co., Ltd.
Contact:+86-519-83131668;83139028;83138042;83137041
Address:JiuliStreet, Benniu Town Changzhou City, Jiangsu Province
Contact:+31-24-3886056
Address:Binderskampweg 29 Unit 36
Contact:+86-577-65618087-605
Address:Room 402, Unit 4 Xinhu Bldg. Waitan Ruian City, Zhejiang China.
Doi:10.1016/j.ejmech.2010.01.040
(2010)Doi:10.1021/jo00023a010
(1991)Doi:10.1248/cpb.39.1866
(1991)Doi:10.1016/S0040-4020(01)85058-4
(1994)Doi:10.1246/bcsj.64.2588
(1991)Doi:10.1021/j100180a035
(1992)
