Synthesis and Evaluation of Glucose-ADP Hybrids as Inhibitors of Hexokinase

DOI: 10.1021/jo00025a033

Source and publish data:

Journal of Organic Chemistry p. 7133 - 7144 (1991)

Update date:2022-09-26

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Authors:

Akerfeldt, Karin S.

Bartlett, Paul A.

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Article abstract of DOI:10.1021/jo00025a033

Glucose-ADP hybrids, in which carboxamide (4) and linear acetylene (5) and allene (6) functional groups link the two moieties, were designed as potential multisubstrate analogue inhibitors for hexokinase.The diastereomeric aldehydes 15 and 28 were key int

Full text of DOI:10.1021/jo00025a033

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