Synthesis and Evaluation of Glucose-ADP Hybrids as Inhibitors of Hexokinase

DOI: 10.1021/jo00025a033

Source and publish data:

Journal of Organic Chemistry p. 7133 - 7144 (1991)

Update date:2022-09-26

Topics:

Authors:

Akerfeldt, Karin S.

Bartlett, Paul A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00025a033

Glucose-ADP hybrids, in which carboxamide (4) and linear acetylene (5) and allene (6) functional groups link the two moieties, were designed as potential multisubstrate analogue inhibitors for hexokinase.The diastereomeric aldehydes 15 and 28 were key int

Full text of DOI:10.1021/jo00025a033

Products guided by the article

Product name:3,5-O-(R)-benzylidene-6-cyano-6-deoxy-1,2-O-isopropylidene-α-D-glucofuranose

Cas No:136839-36-6

R&D Labs maybe for 136839-36-6

Rizhao Lanxing Chemical Indusrial Co.,Ltd

Contact:86-633-2616708

Address:NO.15 West road Shenglan, Lanshan district, Rizhao City
Quzhou Aokai Chemical Co., Ltd.

Contact:86-570-3032832

Address:NO.16 , Laodong Road,Quzhou City, Zhejiang Province,China
Zhengzhou Minzhong Pharmaceutical Co.,ltd

Contact:0086-371-65797115

Address:15/F,Jiangshan Bldg, NO.126 Huanghe Road,Zhengzhou, China
Goldwills Pharmaceuticals Co., Ltd.

Contact:0916-2237889 13991621155

Address:North Suburb of Hanzhong city, Shaanxi Province
Tianjin Emulsion Science&Technology Development Co.,Ltd

Contact:13901380442

Address:Vake Garden New Town New Yi Bai Road Beichen District Tianjin,China

Relevant to this article

Synthesis and pairing properties of oligodeoxynucleotides containing bicyclo-RNA and bicyclo-ANA modifications

Doi:10.1021/jo300554w
(2012)
A new synthesis of nitriles from N-alkoxyimidoyl halides with zinc

Doi:10.1055/s-1991-26566
(1991)
Switch in site of inhibition: A strategy for structure-based discovery of human topoisomerase IIα catalytic inhibitors

Doi:10.1021/acsmedchemlett.5b00040
(2015)
Synthesis of fluorinated oxadiazoles with gelation and oxygen storage ability

Doi:10.1039/c2ob07024c
(2012)
A C₂-symmetric chiral 2,2'-bipyridine derived from tartaric acid

Doi:10.1080/00397919108021582
(1991)
SYNTHESIS AND HEPATOPROTECTANT ACTIVITY OF 5-CARBAMOYL- AND 5-ACETYL-2-ALKYLTHIO-6-METHYL-4-ARYL-3-CYANO-1,4-DIHYDROPYRIDINES

Doi:10.1007/BF00772003
(1991)

Article Doi