Structure elucidation of restriction, a novel antifungal agent from Penicillium restrictum

Article abstract of DOI:10.1016/S0040-4020(01)86432-2

The structures and absolute stereochemistry of restriction (1), its N,N-dimethyl derivative (4) and desglycyl hydrolysis product (3), isolated from Penicillium restrictum, have been determined on the basis of spectroscopic evidence. They belong to a new class of broad spectrum antifungal agents representing substituted tetrahydropyranyl ethers incorporating triene and glycyl ester side chains.