Synthesis, antiproliferative, and antiviral activity of certain 4- aminopyrrolo[2,3-d]pyridazine nucleosides: An entry into a novel series of adenosine analogues

Article abstract of DOI:10.1021/jm00081a014

The preparation of novel heterocyclic base modified adenosine analogues, the 4-aminopyrrolo[2,3-d]pyridazine nucleosides, is described. Crucial to their successful preparation was the use of the pyrrole glycoside intermediates 3-cyano-2-formyl-1-(2,3,5-tr