Diazeniumdiolated carbamates: A novel class of nitric oxide donors

DOI: 10.1016/j.bmc.2012.01.046

Source and publish data:

Bioorganic and Medicinal Chemistry p. 2025 - 2029 (2012)

Update date:2022-08-06

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Authors:

Nandurdikar, Rahul S.

MacIag, Anna E.

Cao, Zhao

Keefer, Larry K.

Saavedra, Joseph E.

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Article abstract of DOI:10.1016/j.bmc.2012.01.046

We report an indirect method for synthesis of previously inaccessible diazeniumdiolated carbamates. Synthesis involves use of previously reported triisopropylsilyloxymethylated isopropylamine diazeniumdiolate (TOM-ylated IPA/NO). These novel diazeniumdiolated carbamate prodrugs upon activation release nitric oxide (NO) similar to their secondary amine counterparts. They are also efficient sources of intracellular NO. These prodrugs may have potential applications as therapeutic NO-donors.

Full text of DOI:10.1016/j.bmc.2012.01.046

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