Cytotoxic 1,2,3-Triazoles as Potential Leads Targeting the S100A2-p53 Complex: Synthesis and Cytotoxicity

DOI: 10.1002/cmdc.202000950

Source and publish data:

ChemMedChem p. 2864 - 2881 (2021)

Update date:2022-08-05

Topics:

Authors:

Sun, Jufeng

Baker, Jennifer R.

Russell, Cecilia C.

Cossar, Peter J.

Ngoc Thuy Pham, Hong

Sakoff, Jennette A.

Scarlett, Christopher J.

McCluskey, Adam

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1002/cmdc.202000950

In silico screening predicted 1 (N-(4-((4-(3-(4-(3-methoxyphenyl)-1H-1,2,3-triazol-1-yl)propyl)piperazin-1-yl) sulfonyl)-phenyl)acetamide) as an inhibitor of the S100A2-p53 protein-protein interaction. S100A2 is a validated pancreatic cancer drug target.

Full text of DOI:10.1002/cmdc.202000950

Products guided by the article

Product name:2-(4-nitrophenylsulfonylamino)ethyl methanesulfonate

Cas No:1370451-29-8

R&D Labs maybe for 1370451-29-8

Zhangjiagang Jianing Import & Export Co.,Ltd.

Contact:086-512-55379012 13913607595

Address:NO.1 Guotai North Road Zhangjiagang Economic Development Zone,215600,Jiangsu,China
Shijiazhuang Haotian Chemical Co., Ltd.

Contact:86-311-85044374

Address:293 Donggang Road
Anhui Qingyun Pharmaceutical and Chemical Co.,Ltd

Contact:+86-551-63633067

Address:Shuangfeng Road Hefei Anhui
Zhuhai Jiacheng Biological Technology Co., Ltd

Contact:0756-8800233

Address:room 222, Lianhua road , Gongbei ,Zhuhai, Guangdong ,China
Nanjing Norris Pharm Technology Co., Ltd.

Contact:+86-13901585132

Address:2 Qiande Road, Jiangning sciencepark Hi-Tech Zone, Nanjing, P.R.China

Relevant to this article

Structural requirements essential for elastin coacervation: Favorable spatial arrangements of valine ridges on the three-dimensional structure of elastin-derived polypeptide (VPGVG)n

Doi:10.1002/psc.1394
(2011)
Alkene functionalization for the stereospecific synthesis of substituted aziridines by visible-light photoredox catalysis

Doi:10.1039/c7cc09151f
(2018)
EFFECT OF THE NATURE OF THE ALKYL RADICAL ON THE BIOLOGICAL ACTIVITYOF N-CARBOXYALKYL DIPEPTIDES

Doi:10.1007/BF00772004
(1991)
Phototriggering of caged fluorescent oligodeoxynucleotides

Doi:10.1021/ol047729n
(2005)
Design, synthesis and antifibrotic activities of carbohydrate-modified 1-(substituted aryl)-5-trifluoromethyl-2(1H) pyridones

Doi:10.3390/molecules17010884
(2012)
CuCl-K₂CO₃-catalyzed highly selective borylcupration of internal alkynes - Ligand effect

Doi:10.1039/c2ob26147b
(2012)

Article Doi