NEW OPTICALLY RESOLVED PERFLUORO(2-DIALKYLAMINO-PROPIONIC ACIDS)

Article abstract of DOI:10.1016/S0022-1139(00)80130-X

Optical resolution of several perfluoro(2-dialkylamino-propionic acids) having a perfluorodimethylamino-, a perfluoropyrrolidino-, a perfluoromorpholino or a perfluoropiperidino-group as the perfluorodialkylamino substituent has been conducted.Among them, those having a perfluorocyclic amino group were successfully resolved into optically pure (+)- and (-)-perfluoro(2-dialkylamino-propionic acids) via corresponding diastereomeric amides by means of column chromatography.However, in the case of perfluoro(2-dimethylamino-propionic acid), the separation of its diastereomeric amides could not be achieved under the same procedure adopted for those having cyclic amino substituents.