Direct vinylogous aldol reaction triggered by tetrabutylammonium fluoride: A highly regioselective and diastereoselective addition of cyclic β-haloenals to aromatic aldehydes

Article abstract of DOI:10.1055/s-0031-1290313

A new type of direct vinylogous aldol addition between cyclic β-haloenals and aromatic aldehydes promoted by TBAF has been developed. The reaction was carried out under mild conditions to provide highly functionalized δ-hydroxy-β-halo-α,β-unsaturated aldehydes with high diastereomeric ratios and low to good yields. Georg Thieme Verlag Stuttgart · New York.