Methoxy and hydroxy derivatives of 3,4-dihydro-3-(di-n-propylamino)-2H-1-benzopyrans: New synthesis and dopaminergic activity

Article abstract of DOI:10.1016/0223-5234(91)90145-D

The synthesis of methoxy and hydroxy derivatives of 3,4-dihydro-3-(di-n-propylamino)-2H-1-benzopyran from readily available or commercial o-hydroxybenzaldehydes is described in six steps. The enantiomers of 8-hydroxy-3,4-dihydro-3-(di-n-propyl-amino)-2H-1-benzopyran 1b have been resolved. It is shown that the compound (-)-1b is a mroe selective D-2 agonist, compared to apomorphine.