Synthesis of [Tyr-5-Ψ(CH2NMe)-Tyr-6]RA-VII, a reduced peptide bond analogue of RA-VII, an antitumor bicyclic hexapeptide

Article abstract of DOI:10.1016/j.bmcl.2012.02.093

A reduced peptide bond analogue of RA-VII, [Tyr-5-Ψ(CH ₂NMe)-Tyr-6]RA-VII (3), was designed and synthesized. The key reduced cycloisodityrosine unit was prepared by reduction of the cycloisodityrosine derived from natural RA-VII, followed by co