Alternative Strategies for the Fmoc Solid-Phase Synthesis of O4-Phospho-L-tyrosine-Containing Peptides

Article abstract of DOI:10.1002/hlca.19910740621

A number of biologically relevant O⁴-phospho-L-tyrosine-containing peptides have been synthesized by either the global phosphorylation of the side-chain-unprotected L-tyrosine moiety in presynthesized resin-bound peptides or alternatively by the incorporation of suitable protected O⁴-phospho-L-tyrosine building blocks in the continuous-flow method of Fmoc solid-phase peptide synthesis.Different phosphate-protecting groups have been applied.