Nucleosides and nucleotides. 103. 2-Alkynyladenosines: A novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects

Article abstract of DOI:10.1021/jm00080a007

The synthesis and receptor-binding activities at A₁ and A₂ adenosine receptors for a series of 2-alkynyladenosines are described. The palladium- catalyzed cross-coupling reaction of 2-iodoadenosine (4a) with various terminal alkynes