1β-methyl-2-(5-substituted pyrrolidin-3-ylthio)carbapenems; 1. Synthesis and antibacterial activity of BO-2502A and its related compounds

Article abstract of DOI:10.7164/antibiotics.50.567

The synthesis and biological activity of (1R,5S,6S)-2-[(3S,5S)-5-substituted pyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3 -carboxylic acid, in which lactams and cyclic amines are introduced as substituents, are described. They sh