Boron Trifluoride Assisted Perfluoroalkylation of Carbon-Nitrogen Double Bonds

DOI: 10.1021/jo00031a032

Source and publish data:

Journal of Organic Chemistry p. 1504 - 1513 (1992)

Update date:2022-08-04

Topics:

Authors:

Uno, Hidemitsu

Okada, Shin-ichiro

Ono, Tetsushi

Shiraishi, Yasukazu

Suzuki, Hitomi

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Article abstract of DOI:10.1021/jo00031a032

In the presence of BF3*OEt2, (perfluoroalkyl)lithiums generated in situ from the reaction of primary perfluoroalkyl iodides and MeLi-LiBr reacted with imines, azines, and nitrones to afford perfluoroalkylated nitrogen-containing compounds in moderate to good yields.This method was successfully applied to the preparation of a (perfluoroalkyl)glycine and optically active perfluoroalkylated amines.

Full text of DOI:10.1021/jo00031a032

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