Boron Trifluoride Assisted Perfluoroalkylation of Carbon-Nitrogen Double Bonds

Article abstract of DOI:10.1021/jo00031a032

In the presence of BF3*OEt2, (perfluoroalkyl)lithiums generated in situ from the reaction of primary perfluoroalkyl iodides and MeLi-LiBr reacted with imines, azines, and nitrones to afford perfluoroalkylated nitrogen-containing compounds in moderate to good yields.This method was successfully applied to the preparation of a (perfluoroalkyl)glycine and optically active perfluoroalkylated amines.