Phosphonate Analogues of Chorismic Acid: Synthesis and Evaluation as Mechanism-Based Inactivators of Chorismate Mutase

DOI: 10.1021/jo00027a034

Source and publish data:

Journal of Organic Chemistry p. 178 - 184 (1992)

Update date:2022-09-26

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Authors:

Wood, Harold B.

Buser, Hans-Peter

Ganem, Bruce

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Article abstract of DOI:10.1021/jo00027a034

The mechanism of chorismate mutase, the enzyme which catalyzes the Claisen arrangement of chorismic to prephenic acid, remains a fascinating area for bioorganic research.This paper describes the enantioselective synthesis of phosphonochorismic acids 3 and

Full text of DOI:10.1021/jo00027a034

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