Baker's yeast reduction of arylalkyl and arylalkenil γ- and δ-keto acids

DOI: 10.1016/S0040-4020(01)81944-X

Source and publish data:

Tetrahedron p. 7887 - 7896 (1991)

Update date:2022-08-05

Topics:

Authors:

Aquino, Mario

Cardani, Silvia

Fronza, Giovanni

Fuganti, Claudio

Fernandez, Rosalino Pulido

Tagliani, Auro

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Article abstract of DOI:10.1016/S0040-4020(01)81944-X

γ- and δ-Lactones 5, 6, 13, 14, 15 and 16 were synthesized via baker's yeast reduction of the corresponding keto acids 3, 4 and 9-12. The enantioselectivity of the reduction is strongly dependent on the nature of the keto acid; the δ-lactones ware always obtained in an ee% higher than the γ-lactones and ranging from 70% to 100%.

Full text of DOI:10.1016/S0040-4020(01)81944-X

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