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C-Aryl 5a-carba-β-d-glucopyranosides as novel sodium glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes

DOI: 10.1016/j.bmc.2012.04.053

Source and publish data:

Bioorganic and Medicinal Chemistry p. 4117 - 4127 (2012)

Update date:2022-08-04

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Authors:

Ohtake, YoshihitoOhtake, Yoshihito

Sato, TsutomuSato, Tsutomu

Matsuoka, HiroharuMatsuoka, Hiroharu

Kobayashi, TakamitsuKobayashi, Takamitsu

Nishimoto, MasahiroNishimoto, Masahiro

Taka, NaokiTaka, Naoki

Takano, KojiTakano, Koji

Yamamoto, KeisukeYamamoto, Keisuke

Ohmori, MasayukiOhmori, Masayuki

Higuchi, TakashiHiguchi, Takashi

Murakata, MasatoshiMurakata, Masatoshi

Morikawa, KazumiMorikawa, Kazumi

Shimma, NobuoShimma, Nobuo

Suzuki, MasayukiSuzuki, Masayuki

Hagita, HitoshiHagita, Hitoshi

Ozawa, KazuharuOzawa, Kazuharu

Yamaguchi, KojiYamaguchi, Koji

Kato, MotohiroKato, Motohiro

Ikeda, SachiyaIkeda, Sachiya

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Article abstract of DOI:10.1016/j.bmc.2012.04.053

C-Aryl 5a-carba-β-d-glucopyranose derivatives were synthesized and evaluated for inhibition activity against hSGLT1 and hSGLT2. Modifications to the substituents on the two benzene rings resulted in enhanced hSGLT2 inhibition activity and extremely high h

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Full text of DOI:10.1016/j.bmc.2012.04.053

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