European Journal of Medicinal Chemistry p. 599 - 604 (1991)
Update date:2022-09-26
Topics:
Dannhardt, G
Meindl, W
Schober, B D
Kappe, T
4-Hydroxy-3-phenylpyridin-2 (1H)-ones with different substituents either at N-1 or in the phenyl group were synthesized by reaction of ethyl β-aminocrotonates with dialkyl malonates or 'magic malonates' (2,4,6-trichlorophenyl malonates).The evaluation of these compounds on Mycobacterium tuberculosis H37Ra, Escherichia coli B and Staphylococcus aureus ATCC 25923 showed significant inhibitory effects on M tuberculosis (5g and 5s, MIC=8μg/ml).A structure-activity relationship is discussed.
View MoreContact:+86-512-56795332
Address:No227 Shuanglong Rd, Fenghuang, Zhangjiagang
Taizhou Huading Chemical Co.,Ltd(expird)
Contact:+86-576-88583898
Address:Economic&Technology development zone,Taizhou City,Zhejiang Province,China
Nanjing Vincero International Trading Co.,Ltd
Contact:8618936897229
Address:NO.68, ZhuShan Road, JiangNing WanDa Plaza, Building E Room 1703
Shanghai Kangxin Chemical Co., Ltd
Contact:+86 21 60717227
Address:118,Ganbai Village,Waigang Town,Jiading District,Shanghai
Suzhou Kangrun Pharmaceutical, Inc
Contact:86-512-63912376,63913329
Address:Building 2, No. 2358 ,Chang'an Rd, Wujiang Economic Development Zone Pioneering park, china
Doi:10.1021/jo01357a616
(1957)Doi:10.1021/jo00060a029
(1993)Doi:10.1016/j.jorganchem.2013.10.040
(2014)Doi:10.1039/d0nj00829j
(2020)Doi:10.1016/S0040-4039(03)01460-6
(2003)Doi:10.1007/BF00961058
(1991)