N-aryl modification in-lactam: Design and synthesis of novel monocyclic-lactam derivatives as inhibitor for bacterial propagation

Article abstract of DOI:10.1080/00397911.2011.574807

In search of novel γ-lactam antibacterial agents as non-lactam mimics of some γ-lactam antibiotics, N-aryl modification in the γ-lactam ring has been made to synthesize compounds 4-8 in two to six steps. Compound 4 was synthesized using the intermolecular