Synthesis of 1S,2R,3S,4R,5R-methyl[2,3,4-trihydroxy-5-(hydroxymethyl)cyclopentyl]amine: A potent α-mannosidase inhibitor

Article abstract of DOI:10.1016/S0040-4039(00)97253-8

The title carbocyclic amine 15, prepared in high yield from isoxazolidine 8 using an efficient oxidation-epimerization-reduction sequence, is an inhibitor of mung bean α-mannosidase II and a potent inhibitor of jack bean α-mannosidase.