Palladium-Catalyzed Synthesis of Amides and Peptides

DOI: 10.1016/0040-4039(91)80241-W

Source and publish data:

Tetrahedron Letters p. 6633 - 6636 (1991)

Update date:2022-08-04

Topics:

Authors:

Roos, Eric C.

Bernabe, Pablo

Hiemstra, Henk

Speckamp, W. Nico

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Article abstract of DOI:10.1016/0040-4039(91)80241-W

When the Pd(0)-catalyzed hydrostannolysis of the N-allyloxycarbonyl group is carried out in the presence of an activated carbonyl compound, a coupling product is formed.This new method appears to be applicable to the synthesis of a wide range of amides and peptides.Key Words: allyloxycarbonyl, palladium(0), amides, peptide coupling, amino acids

Full text of DOI:10.1016/0040-4039(91)80241-W

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