Design, synthesis characterization and in vitro biological activity of a series of 3-aryl-6-(bromoarylmethyl)-7H-thiazolo[3,2-b]-1, 2, 4-triazin-7-one derivatives as the novel acetylcholinesterase inhibitors

Article abstract of DOI:10.1016/j.cclet.2012.04.022

Bromination is used as a strategy to improve biological activity in medicinal chemistry. In order to study on the structure-activity relationships of the novel acetylcholinesterase inhibitors with 7H-thiazolo[3,2-b]-1, 2, 4-triazin-7-one scaffold, based o