Renin inhibitors containing α-heteroatom amino acids as P2 residues

Article abstract of DOI:10.1021/jm00084a008

A series of renin inhibitors having α-heteroatom amino acids as P₂ substitutions has been prepared. Examples where the heteroatom is oxygen, sulfur, or nitrogen are described. Many of the compounds exhibit subnanomolar potency when tested in vi