An Intramolecular Addition-Elimination Strategy For The Synthesis Of Carbapenems

DOI: 10.1016/S0040-4020(01)89561-2

Source and publish data:

Tetrahedron p. 12085 - 12096 (1994)

Update date:2022-09-26

Topics:

Authors:

Ziegler, C. B.

Curran, W. V.

Feigelson, G. B.

Bitha, P.

Fabio, P.

et al. et al.

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Article abstract of DOI:10.1016/S0040-4020(01)89561-2

The synthesis of 2-<(4-fluorophenylsulfonyl)methyl> carbapenem carboxylate 20 is described.The key step is a base mediated addition-elimination ring closure of a iodovinyl sulfone 12.

Full text of DOI:10.1016/S0040-4020(01)89561-2

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